The Shale gas resources in China are abundant and exhibits significant exploitation potential. However, during the development of shale gas, horizontal well casings often suffer severe, deformation due to engineering and geological factors. Which hinders the implementation of subsequent fracturing and production enhancement operations, thereby limiting the productivity of oil and gas wells. Liquid colloidal plugs (LCPs), which exhibit unique rheological and phase-change properties, have emerged as promising candidates for bridge plugs in fractured casing fracturing operations. Nevertheless, there is currently a lack of research on the sealing performance of LCPs in deformed casings. Therefore, this paper takes the LCP composed of functional polyacrylamide TSRP and polyethyleneimine (PEI) as the research object. Through basic performance evaluation, the feasibility of using it as a bridge plug for fracturing is clarified. Based on actual deformed casing conditions observed in the Luzhou area of southern Sichuan, a LCP sealing pressure test platform was established. The sealing pressure of the LCP was evaluated at various lengths and types of deformed casing, and a sealing pressure chart applicable to different configurations of deformed well sections. Furthermore, based on the experimental results, the grey correlation analysis method was employed to develop a predictive model for the sealing pressure of LCP in deformed casing. Which incorporates parameters such as the length of deformation in section 1 and section 2, the sealing length in section 1 and section 2, and the sealing diameter in section 1 and section 2, thereby offering practical guidance for field applications.