In drilling operations in Canadian oil sands, the problem of reduced operational efficiency caused by asphalt adhering to drilling components is urgent to be addressed. However, this issue is rarely encountered domestically, and there are no effective solutions or relevant evaluation schemes to draw upon, making the research extremely challenging. This paper focuses on asphalt solidification technology, drawing inspiration from the mechanism of inorganic solidifying agents releasing active oxygen atoms at high temperatures to reconstruct oil sand components. For the first time, asphalt penetration is introduced as the main performance indicator in this study. Six commercially available typical inorganic solidifying agents are selected and thermally aged in aging tanks with Canadian oil sands. The study examines the changes in oil sand penetration, simulated steel rod adhesion, and the impact on drilling fluid performance before and after solidification, systematically studying their performance. The research indicates that sodium thiosulfate, anhydrous sodium acetate, and potassium persulfate in the inorganic solidifying agents exhibit significant solidification efficiency, reducing the asphalt penetration value from 108/0.1mm to 25.89/0.1mm with long-term stability. Among them, the sodium thiosulfate system demonstrates the best inhibitory effect in the steel rod adhesion test, significantly reducing the asphalt adhesion rate from 50.93% to 6.71%. Furthermore, while the solidification of oil sands has minimal impact on the rheological properties of the drilling fluid system, it can lead to increased filtration loss and negative effects such as simulated drill tool corrosion. In the mechanism research section, Fourier Transform Infrared Spectroscopy (FT-IR) analysis reveals that the active ions (such as CH?COO?, SO?2?) in the solidifying agents undergo chemical cross-linking reactions with the polar functional groups (hydroxyl, carboxyl) in asphalt. Four-component analysis finds that the solidifying agents promote the transformation of low molecular weight saturated hydrocarbons and aromatic hydrocarbons in asphalt components into high molecular weight colloids and asphaltenes. Sodium thiosulfate, anhydrous sodium acetate, and potassium persulfate can increase the content of high molecular weight components by 153%, 215%, and 615%, respectively. Scanning Electron Microscopy (SEM) and wax crystal morphology analysis further confirm that the microstructure of solidified asphalt forms a porous network skeleton, leading to increased porosity in the filter cake, which in turn exacerbates the increase in filtration loss of the drilling fluid. This study reveals the mechanism of action between inorganic solidifying agents and oil sand asphalt for the first time, providing a theoretical basis for solving the adhesion problem in oil sand drilling.