The wettability of the rock has an important influence on the delay of the water coning recovery after the bottom water reservoir is pressed, but the degree of its influence is not clear. In view of this, four wetting adjustment systems with different wetting abilities were constructed with the contact angle as the index of wetting agent, which were dissolved in oil-soluble viscosity reducer, and their properties were evaluated. On this basis, the intrinsic relationship between wettability and production property conditions was quantitatively described, and the degree of influence of wettability on inhibiting water coning recovery was further illustrated. The results show that the reservoir under the action of oil wetting agent has the best effect of inhibiting bottom water recovery, the equilibrium pressure ratio reaches 3.75, and the net recovery degree increases by 15.17%. However, the equilibrium pressure ratio of the reservoir under the action of strong water wetting agent is only 0.54, and the net recovery is increased by 6.51%. There is an obvious regularity between wettability and produced physical properties. Adjusting the wettability of the reservoir can effectively restrain the rise of the water cone and improve the oil recovery.