In view of the water blocking damage problem faced in the process of oil exploitation and the current situation that traditional fluorine-based waterproof lock agents are expensive and cause water pollution，in the paper，the emulsified silicone oil was used to replace fluoride and a non-fluorine waterproof lock agent J-C-0 was prepared with surfactant octadecyl trimethyl ammonium chloride as the emulsifier. The surface tension，interfacial tension，wettability，contact angle and self-imbibition of the agent were tested and compared with that of fluorine-based water blocking agents，namely perfluorononenoxy benzene sulfonate （OBS），and fluorinated acrylate copolymer（PFAc）. The research results showed that when the mass ratio of dimethyl silicone oil to octadecyl trimethyl amine was 8∶1 and the dosage was 0.3%，the surface tension of the waterproof lock agent J-C-0 system could be reduced to 26 mN/m. The waterproof lock agent J-C-0 system could increase the contact angle of the core from 23.71° to 88.93°， changing the wettability of the core from strong hydrophilicity to weak hydrophilicity. Compared with the waterproof lock agents OBS and PFAc，J-C-0 had better temperature and salt resistance. The waterproof lock agent J-C-0 had lower spontaneous imbibition water amount and higher permeability recovery rate. The permeability recovery rate of the core treated with 2% NaCl + 0.3% J-C-0 was 83.51% . As a non-fluorine waterproof lock agent，J-C-0 performes excellently in reducing water lock damage，has a good application prospect，and is expected to solve many problems of traditional fluorine-based water blocking agents.