Conventional plugging materials are often difficult to balance the structural characteristics of deformability and high pressure，resulting in poor particle size matching and pressure sealing effect. Although existing shape memory plugging materials can deform at activation temperature and achieve adaptive sealing of cracks，they have problems such as low activation temperature and insufficient compressive strength，making it difficult to cope with harsh temperature and pressure environments in deep geological conditions. In response to these issues，a foaming resin material（SMFM）with high activation temperature and good shape memory performance was developed by using epoxy resin monomer（E51），curing agent triethylenetetramine（TETA）and polyetheramine（DP），and acrylic copolymer microspheres（PM）as raw materials. The pressure plugging performance and wall strengthening effect of SMFM were systematically evaluated. The results showed that when the mass ratio of E51，TETA，DP and PM was 0.05∶0.02∶0.02∶1.00，SMFM had good response performance，with a response rate of 92.9% . The glass transition temperature was 97 ℃，and then the recovery temperature was 130 ℃. Furthermore，the pressure bearing capacity could reach 10.3 MPa when the formula of plugging agent was made up of base paste and 5% SMFM，which had a good sealing effect on natural crack leakage. SMFM could adaptively match the crack width into the crack by changing its shape. After reaching activation temperature，it expanded from sheet materials or elliptical microspheres into block materials or circular microspheres，rapidly bridging in the crack，expanding under pressure，filling and sealing，and synergistically forming a sealing layer to reduce underground leakage and strengthen the wellbore. The plugging fluid formulated with high activation temperature shape memory foam material could be applied to high-temperature deep well crack leakage sealing.