For high-temperature and high-salinity oil reservoirs，the traditional anionic and nonionic surfactants are easily deactivated and cannot achieve the best oil recovery effect. Anionic-nonionic surfactants have both advantages，showing good interfacial activity，high temperature resistance and high salinity resistance，which possess great potential applications in EOR. Using aliphatic alcohol polyoxyethylene ethers（AEO7，AEO9）and nonylphenol polyoxyethylene ethers（NP7，NP9）with EO number of 7 and 9 as raw materials，anionic-nonionic surfactants with sulfonic acid groups，named as AESO7，AESO9，NPSO7， NPSO9，was synthesized by sulfonylation method，with a yield of 70% . The surface activity，salt resistance，temperature resistance and other properties of products were determined. The results showed that the surface tensions of AESO7 and NPSO7 solutions at the critical micelle concentration were 27.16 and 28.67 mN/m，which were lower than that of AESO9 and NPSO9 solutions. In the seawater solution with the salinity of 10—100 g/L，four surfactants showed good salt resistance and the surface tension remained stable. As the temperature increased，the water separation rate of AESO9、NPSO9 emulsion were larger than that of AESO7、NPSO7. At the temperature of 60—80 ℃，the water separation rates of the emulsion，prepared through mixing 10 g/L surfactant solutions and kerosene with volume ratio of 1∶1，remained relatively stable，indicating the temperature resistance of the modified surfactants had been significantly improved. When AESO7，AESO9 and α-cyclodextrin（α-CD）were compounded at the mass ratio of 1∶2，the surface tension of the complex system at the critical micelle concentration was further reduced，and the emulsion stability was improved by approximately 10% compared with that of the single system under different temperatures， which also remained relatively stable in simulated seawater（10—100 g/L），and had excellent salt-resistance.