The Existing mobility control systems face technical challenges in medium-to-low permeability reservoirs，such as blocking effectively but unable to travel far，or traveling far without adequate blocking. In this paper，the nano-scale resin particle dispersions （OSR） suitable for deep mobility control in medium-to-low permeability reservoirs were prepared via a high-temperature and high-pressure melting method，using surfactants as dispersing stabilizers. The injection performance and plugging ability of OSR in medium-low permeability porous media were systematically evaluated by core displacement experiment with displacement pressure as index. The experimental results indicated that OSR exhibited good injection performance and plugging ability. As the resin concentration in OSR increased，the injection pressure of OSR also increased，but remained at a relatively low level. When the resin content in OSR was 5%，it demonstrated good injection performance in the cores with different permeability，with the maximum injection pressure of less than 0.25 MPa for injecting 1 PV of OSR. As the resin content increased， the plugging efficiency of OSR improved，but after the resin content exceeded 5%，the change in plugging efficiency became negligible. At a fixed resin content of 5%，the plugging efficiency increased as the permeability of the core decreased，with a plugging efficiency of over 90% for cores with a permeability of less than 30 × 10^-3 μm². Furthermore，OSR demonstrated good erosion resistance in the cores with different permeabilities.