Aimed at the engineering problems of high pressure and limited displacement caused by high temperature and low permeability and high closure stress in deep oil and gas reservoirs，in this paper，a high-flow rate full-size resistive testing device was independently designed and constructed，and took the guar gum fracturing fluid system weighted with inorganic and organic salts as the research object，the influence of different weighting agent types and concentration on the friction characteristics of fracturing fluid was systematically explored. The experimental results showed that the friction drag of the weighted brine increased significantly with the increase of salt concentration and flow rate，and the flow rate sensitivity of the inorganic salt system was significantly higher than that of the organic salt system. The friction drag of the guar gum based fluid reduced due to ionic inhibition effect under the condition of low weighting concentration，density being of 1.20—1.35 g/cm³，and the friction drag increased under the condition of high weighting concentration，the density being higher than 1.40 g/cm³，due to the synergistic effect of the ionic strength and the cross-linking network steric hindrance. At the level of cross-linking kinetics，the organic salt could accelerate the cross-linking reaction and improve the friction drag at low concentration，while the high concentration of the organic salt inhibited the cross-linking process due to the pH value regulation，slowing down the growth rate of friction drag. The friction characteristics of the gel were significantly regulated by the concentration threshold of the weighting agent，when the density of the organic salt system was 1.40 g/cm³，the increase of friction drag was slowed down due to the transformation of flow pattern. The research results can provide data reference for the design of salt-resistant weighting and optimization of low friction drag of fracturing fluids in deep oil and gas reservoirs.