In order to solve the problems of inefficient，ineffective circulation of injected water and imbalanced injection and production in the later stage of oilfield development due to intensified contradictions in reservoir profile and development of dominant channel of water flow，a temperature and salt resistant gel profile control system was developed using hydrophobic associating ploymer as the main agent，organic aluminum zirconium crosslinking agent made from inorganic salt aluminum and zirconium oxychloride as the main crosslinking agent，and sodium lignosulfonate heat stabilizer as the auxiliary. Its gelling performance，anti-dilution performance，shear resistance，plugging performance and erosion resistance were studied. The optimal formula for the profile control system was as follows：0.4% hydrophobic associating polymer，0.3%—0.35% organic aluminum zirconium crosslinking agent and 0.2% heat stabilizer. The research results indicated that the viscosity of the base liquid was 88.3—95.8 mPa·s，and the low viscosity base fluid endowed with better pumping performance，which could ensure the construction safety. Under the condition of 200 ℃ and salinity of 27 123.5 mg/L，the gelation viscosity of the system within 90 d could be maintained above 6000 mPa·s，and the viscosity retention rate could reach above 80%. When diluted with 60% of the formation water，the gelation viscosity of the system could still reach over 4000 mPa·s，and the dilution after gelation had a smaller impact on the gelation strength of the system. The system has good migration ability in cores with permeability of 500×10^-3，1000×10^-3 and 2000×10^-3 μm²，respectively，and the pressure gradually stabilized at a distance greater than 50 cm from the injection end of the rock core，and plugging rate was over 80%. With the displacement of a large amount of injected water，the permeability of the injected profile control system remained basically unchanged，exhibiting good erosion resistance.