Acidizing and acid fracturing reservoir reconstruction technology is an important means to increase production. Traditional dry powder acid thickener has a dissolution time of more than 2 h when used to prepare acid solution，which makes it impossible to continuously mix on site. As for the emulsion thickener with better solubility，acid resistance，salt resistance and shear resistance in special environment need to be improved. In this paper，using APS/TEMPO composite catalyst，acrylamide （AM），fluorine-containing，sulfonate-containing and ammonium chloride-containing monomers as raw materials，a self-healing， quick-dissolving and hydrochloric acid-resistant thickener PASD based on strong amphiphobic interaction was prepared by inverse emulsion polymerization. The chemical structure of PASD was characterized by infrared spectroscopy，and its relative molecular mass，stability，acid resistance，acid dissolution time，temperature resistance，salt resistance，shear resistance，amphiphobic inversion and displacement performance were tested. The thickener PASD had excellent chemical stability. When the concentration of inorganic salt ions was less than 50 mg/L，the viscosity could be maintained above 24 mPa·s. PASD could be dissolved in 20 % hydrochloric acid within 3 min，and the viscosity of tackifying acid could reach up to 38 mPa·s. When destroyed by strong shear，the viscosity self-healing rate of the tackifying acid was 65% within 30 min. The gel breaking liquid of PASD tackifying acid could result in wettability reversal of rock with strong-amphiphobic（super-hydrophobic and strong oleophobic），reduce capillary action and driving pressure，and communicate with the pore cracks of the formation to a greater extent. This study provides a material basis for the realization of on-line mixing of acid liquid and the integration of thickened acid fracturing and replacement.