In order to remove strontium barium sulfate scale generated during the development of oil and gas fields，which is characteristic of dense scaling，low solubility，and insoluble in acids and alkalis，the chemical scaling technology was adopted. Firstly，a chelating agent was selected，and then different additives were added to utilize their synergistic and modifying effects. The optimal formulation of barium sulfate/strontium scale remover was determined through single factor experiments as follows， 10% DTPA+ 6% salicylic acid+0.03% potassium polyacrylate concentration+ 0.2% Tween-80. The effects of pH，temperature，and reaction time on the scale removal effect were also investigated. The results showed that the best scale removal effect was achieved when the pH value was 12，the temperature was 80 ℃ ，and the scale removal time was 8 hours. Under these conditions，the descaling rates of barium sulfate，strontium sulfate，and actual scale samples were 79.41%，80.56% and 59.7%，respectively. The scale remover had the advantages of high scale removal efficiency，short scale removal time and low cost，and had broad application prospects in oil and gas field scale removal.