The incompatibility between injected water and formation water often leads to serious sulfate scaling in offshore oilfield. In order to effectively prolong the squeeze life of scale inhibitor，the adsorption enhancer was added in the pre-liquid to improve the adsorption amount of scale inhibitor in the formation and reduce the desorption rate of scale inhibitor. The quaternary ammonium salt surfactant dodecyl trimethyl ammonium chloride（DTAC）and cationic Gemini surfactant amide Gemini quaternary ammonium salt（GS-A6）were selected as the adsorption enhancers，and sodium polyacrylate（PAAS）as the scale inhibitor. The compatibility between adsorption enhancer and scale inhibitor，the static adsorption experiment and dynamic adsorption-desorption experiment were carried out. The results showed that at 120 ℃，the compatibility between the two adsorption enhancers and scale inhibitor was good，and the adsorption capacity of scale inhibitor in the formation could be increased to more than 3 times. When the oil saturation increased from 0 to 80%，the squeeze life of PAAS decreased from 1500 PV to about 1300 PV after DTAC pretreatment. Under different concentrations and oil saturations，GS-A6 had a squeeze life of more than 1500 PV，which was suitable for the scale prevention of oil wells in different development stages. Compared with DTAC，GS-A6 had the advantages of low critical micelle concentration and high surface activity，which prolonged the squeeze life of scale inhibitor and improved the oil displacement effect.