Aiming at the problems of unsatisfactory injection production ratio in actual oil production and development process of Hua182 well group in Yanchang Oilfield，low production and low energy of development wells，the failure of conventional surfactant causing by high salinity，high calcium and magnesium ions in formation water，a system of surfactant flooding with salt resistance was prepared. Without chelating agent and stabilizer，the system of surfactant flooding consisted of ampholytic gemini surfactant（PPM-12），sodium lauryl polyoxyethylene ether sulfate（AES-12）and dodecyl dimethylamine oxide（OB-2）. The ratio of the compound surfactant was optimized，and then its performance was evaluated. The results showed that the suitable mass ratio of PPM-12，AES-12 and OB-2 was 4∶1∶1—1∶1∶4 when the optimum total dosage of surfactant was 0.3%. Under these condition，the oil-water interfacial tension could reach 10-3 mN/m. It could reach the lowest value（1.2×10^-3 mN/m）when the optimum mass ratio of the three surfactants was 2∶1∶3. The adsorption，emulsification，salt resistance and oil displacing efficiency of the compound surfactant was good. The oil-water interfacial tension was still in the order of 10^-3 mN/mafter six adsorption on the surface of core. It could reach the order of 10^-3 mN/m in the concentration range of calcium and magnesium ions in oilfield. Magnesium ion had the greatest influence on the interfacial tension of the system，followed by calcium ion and sodium ion. When the dosage of oil displacement system was less than or equal to 0.25%，the emulsification water separation time was less than or equal to 2894 s. Meanwhile，the oil-water interface was clear. The average recovery increment of compound surfactant flooding system in high salt and low permeability reservoir was 10.3%. The compound surfactant flooding system had good application prospect in similar reservoirs.