Scaling in oilfield usually leads to the blockage of formation and pipeline，cost increase of development and reduction of oil recovery. Aiming at this problem，barium sulfate scale inhibitor was prepared by using three kinds of chelating agents with good anti-scaling performance，such as sodium polyacrylate with low molecular weight，hydrolyzed polymaleic anhydride and polyaspartic acid. The anti-scaling performance，suspension performance and corrosion performance to pipeline of barium sulfate scale inhibitor were studied. The results showed that the best mass ratio of sodium polyacrylate with low molecular weight， hydrolyzed polymaleic anhydride and polyaspartic acid in barium sulfate scale inhibitor was 2∶2∶3. When the mass concentration of barium ion was 300 mg/L and the temperature was 50 ℃，the scale inhibitor had an excellent anti-scaling effect when the dosage was higher than 12.5 mg/L. When the dosage of scale inhibitor was 100 mg/L，the anti-scaling rate could reach more than 95%. The scale inhibitor had good temperature resistance and low corrosion resistance to pipeline. The scale inhibitor could affect the sedimentation of barium sulfate scale and the normal growth of scale nuclei，which made the structure of obtained scale regular and looser. It was conducive to the subsequent mechanical cleaning treatment and met the normal production need of oilfield.