In order to develop the latex cement slurry system with stable and excellent performance，the key materials of the latex powder cement slurry system were studied，the latex powder cement slurry（LPCS）system was constructed，the performance and micromorphology of the LPCS system were studied，and its field application was carried out. The results showed that latex powder could significantly improve the elastic toughness of cement paste，and the dispersant DIP-S，filtrate reducer FLO-S，retarder REM and defoamer CX66L could effectively adjust the performances of cement slurry. Under the conditions of 60 ℃ and 90 ℃，the fluidity index of the LPCS system constructed with these key materials was greater than 0.5，the consistency coefficient was less than 0.7，the thickening time was 3—5 h，no free liquid was formed，the water loss of cement slurry was less than 50 mL，and the compressive strength was more than 24 MPa. The conventional performances of the latex powder cement slurry were excellent. In addition，at these two temperatures，the minimum elastic modulus of latex powder cement slurry was 5.7 GPa，the maximum impact strength and channeling resistance strength were 2.09 kJ/m² and 7.7 MPa/m²，respectively，which indicating that The LPCS had strong sealing capacity. The micro morphology showed that the polymer membrane structure was formed in the latex powder cement paste，which was helpful to improve the performance of cement slurry. The application effect of the LPCS system in shale gas well cementation was good，indicating that the LPCS system was worth popularizing.