In order to meet the sealing requirements of plugging agents under the conditions of unclear fracture scale，complex pore structure，high temperature and high mineralization reservoir in Tahe oilfield，the styrene-modified polyacrylate self-adhesive resin was prepared by suspension polymerization using butyl methacrylate（BMA），stearyl methyl acrylate（SMA）and styrene（St）as monomers，benzoyl peroxide（BPO）as initiator and polyvinyl alcohol（PVA）as suspending agent. The effects of styrene addition on the resin structure，thermal stability，oil solubility and self-adhesive property were investigated，and the plugging property of resin particle was examined. The results showed that the resin had good thermal stability with a thermal decomposition temperature of 302.95 ℃ and a glass transition temperature of 27.8 ℃ when the dosage of styrene was 40%. The resin was completely oil-soluble after soaking 18 hours in diesel oil at 130 ℃. The viscosity of the resin achieved a maximum value of about 105 mPa· s at 110 ℃. Under simulated reservoir condition，the self-adhesive resin exhibited a good sealing pressure gradient of 1.27 MPa/m.