The pressure bearing capacity of water-absorbent swelling resin plugging agent was poor，while the single rigid particles of calcium carbonate can't plug well，and their particle size can't match with the size of lost circulation fracture，which can't meet the requirements of plugging in drilling plugging. In this paper，four kinds of resins with particle size（mm）< 1.00，1.00～<2.80，2.80～ <4.75 and 4.75～<8.00 were obtained by polymeration reaction，using acrylic acid（AA），acrylamide（AM）and 2-acrylamido-2- methylpropanesulfonic acid（AMPS）as monomers，N，N- methylenebisacrylamide as crosslinking agent，ammonium persulfate sodium bisulfite as initiator，and the drying，crushing and screening treatment. The resin with 4 kinds of particle sizes was compounded with bentonite，ultra- fine calcium carbonate，asbestos fiber and 5 kinds of non spherical calcium carbonate particles. Through the evaluation of plugging effect of gap plate with gap width of 1—4 mm，the particle size and dosage of plugging material were optimized，and a compound plugging formula was formed. The results showed that the resin particles swelled in 15—30 min， and the absorbency of fresh water and 6.0% sodium chloride solution reached 102—234 g/g and 17—23g/g in 360 min，respectively. The compound plugging agent was diluted with fresh water and polysulfonated drilling fluid，and the plugging slurry with density of 1.37 g/cm3 could completely plug the gap plate with gap width of 1—4 mm，and could bear pressure for 10 min under 6.9 MPa， expressing good plugging effect.