Jin-91 block entered the later period of steam huff-puff and was flooded seriously, which lacked the theory of steam flooding in heavy oil reservoir with edge and bottom water. Three layers of inhomogeneous artificial core with 500×10^-3、1000×10^-3、1500×10^-3 μm² permeability were used in experiment. There were 5 producing wells, four assist production wells which were designed for saturating core with oil, four water inlets which were used for modeling sufficient edge water on the right. High permeability (16000×10^-3 μm²) transition with 2 cm width was close to the edge water. The effect of pressure, temperature and distance of water and bottom water on the encroachment sensitivity of edge-bottom water was analyzed. The results showed that When the differential pressure (ΔP) was 0.04, 0.06, 0.08 MPa and the temperature was 45℃, the relationship between instant water influx Q and ΔP was Q=0.0021×e^72.8ΔP×t (t=0~75 h) and Q=0.007×e^51.708ΔP×(t-75)+0.157e^72.64ΔP (t=75~125 h) in early and later stage of the experiment, respectively. When ΔP was small, the relationship between Q and time was approximately linear. With increasing ΔP, the curve of Q appeared inflection point. And the instant water-output tended to be stable at later stage of water invasion. When the temperature increased from 45℃ to 75℃, the water breakthrough time delayed. The effect of temperature on water breakthrough time of producing wells far from edge water was the most obvious. The nearer to edge water, the more serious water logging was. The effect of ΔP to the law of water invasion was the most obvious among water invasion sensitive factors. The result provided evidence for the development of heavy water flooded zone turning to steam drive.