A compound surfactant system of carboxybetaine/alkylamide at mass ratio of 1:1 was achieved, and then the interfacial activity, adsorption resistance and the alteration of three-phase contact angle were studied, besides, flooding experiments were conducted. The results showed that the system could reduce interfacial tension between water and Linpan crude oil to 10-3 mN/m magnitude. After the static adsorption of the quartz sand, the surfactant system still had the lower interfacial tension and good emulsification property. With monitoring three-phase contact angle, the surfactant system made the surface of the core change form hydrophilic to lipophilic, which could reduce the Jamin effect of oil droplets in the low permeability pore and improve the development?result of water injection. Based on weak alkaline water flooding in the field, the oil recovery further was increased by 13% after injecting 1.5 PV surfactant system slug with mass fraction of 0.5%, and the injection pressure dropped. This surfactant system had a certain application value in low permeability oilfield.