There are some problems in the development of the heavy oil reservoir in Shengli Oilfield, such as high viscosity and poor fluidity of crude oil, which the recovery efficiency of the water drive is not ideal. Therefore, the emulsification-stripping system was constructed with the instability coefficient of emulsification, the shrinkage rate of oil film and the minimum emulsifying speed as indexes. The emulsification and stripping ability of different surfactants for heavy oil were evaluated. The compound system of 0.3wt%CBT/ASC（m（CBT）：m（ASC）=3:2） was optimized. The displacement effect of the emulsification-stripping system was evaluated by the laboratory sand-filling flow experiment. The mechanism of its action was studied by a microcosmic model. The results showed that CBT had excellent emulsification performance and significantly reduced interfacial tension for heavy oil, and ASC had good stripping ability for heavy oil. The compound system has excellent emulsification-stripping function, and the enhanced oil recovery rate can reach 14.18%. The research results have important guiding significance for efficient development of heavy oil reservoir.