In this paper, the foam performance of sodium dodecyl sulfate (SLS), sodium dodecyl sulfonate (SDS), sodium dodecylbenzene sulfonate (SDBS) and N-dodecyl-N, N-dimethyl tertiary amine (C12A) equimolar compound solution were studied through foam experiments, and the influence of inorganic salt and oil relative to the foam performance of the compound system. In addition, for the SLS/C12A compound system and SDS/C12A compound system with better foam performance, CO2 response defoaming and N2 heating recovery re-foaming and defoaming experiments were carried out. The research results show that the SLS/C12A compound system has the best foam stability and strong salt tolerance. The anti-oil effect of the SDS/C12A compound system is remarkable, and the two compound systems both show good CO2 responsiveness and reversibility. According to the change of the solution and the change of surface tension after defoaming, the response mechanism is inferred that the protonated C12A and anionic surfactants are electrostatically attracted to form a complex, which precipitates out of the solution, which reduces the surface activity of the solution and accelerates the breaking of the foam.