In order to accurately evaluate the oil elution ability of chemical agent and the adsorption loss of surfactant，polymer， alkali and alkali/surfactant/polymer system（ASP）in chemical flooding process，the dual polarization interferometry technology （DPI）was utilized to evaluate the oil elution ability and the adsorption characteristic of chemical agent system used in district Qidong1 of Karamay oilfield. The results showed that using the mixed solution of toluene and n-heptane with volume ratio of 1∶1 as the solvent，a crude oil film with good uniformity was obtained on the surface of silicon oxide chip under the conditions of 2000 mg/ L crude oil mass concentration，60 s homogenization time and 1000 r/min homogenization speed. When the injection time of chemical agent into the chip was 400 s，single aqueous alkali or single polymer solution could significantly reduce the mass and thickness of oil film on the chip. They had strong elution ability for crude oil. The material mass per unit area on the chip increased by 11.7% and the thickness increased by 25% after single surfactant flooding，indicating strong adsorption between surfactant and crude oil. Under the dual influence of surfactant’s adsorption and alkali and polymer’s desorption，ASP had inferior displacement efficiency. After ASP flooding，the material mass per unit area on the chip increased by 0.2% and the thickness increased by 4.43%. The four chemical agents were arranged according to the oil elution ability in following order：aqueous alkali > polymer solution > ASP > surfactant. The experiment result of core flooding with four chemical agents showed that the oil displacement efficiency of each chemical agent had good correspondence with its crude oil elution ability.