Due to high viscosity and poor fluidity of heavy oil reservoir，it is easy to form organic scale deposition and inorganic solid phase plugging in the near well zone，reducing the permeability of the near well zone and leading to a sharp decline in formation production during the development of oilfield. According to the special reservoir physical properties and plugging types of D11 well and D34-H well in Minghuazhen formation of Bozhong oilfield，TC-4 organic plug removal agent was selected through asphalt dissolution，wax dissolution and viscosity reduction experiments，and the performance of DH-1 non-acid plug removal system was evaluated by the experiments of calcium carbonate dissolution，clay dissolution and core flow. Finally，these two plug removal systems were applied on site. The results showed that TC-4 organic plug removal agent had good dissolution ability on asphalt and paraffin，good viscosity reducing effect，and little damage to reservoir，which was suitable to remove organic plugging. DH-1 non-acid plug removal system had a good retarding speed，corrosion inhibition and scale dissolution ability，which would not cause serious damage to rock skeleton. It had good compatibility with crude oil，and broke emulsion in time during migration， which was suitable to remove inorganic solid phase plugging. After TC-4 organic plug removal agent was used in D11 well，and the combination of organic cleaning with TC-4 organic plug removal agent and DH-1 non-acid plug removal was used in D34-H well， the daily oil production，daily liquid production and the rate of water content of these two wells basically returned to the level before plugging removal. Both of the plugging removal system could solve the plugging problem in heavy oil reservoir.