The MOF-derived plugging and inhibiting agent，rich in amine groups in outside structure，was successfully prepared，employing addition polymerization of the aziridine and the functional organic-inorganic hybrid which was prepared by zinc nitrate hexahydrate，2-methylimidazole and ethylenediamine，and it’s sealing ability，inhibition and compatibility with various drilling fluids were investigated. The agent could greatly reduce the total filtration loss of base slurry due to its excellent plugging performance. The total filtration loss of the 6% bentonite muds was 24 mL，while that of the 3% bentonite +3% agent slurry was only 4.4 mL. The yield point of the slurry system containing 2% agent was only 6.5 Pa as the bentonite reached up to 25%，and the swelling heights of the bentonite in the 2% agent system reduced by 76% compared with in fresh water system. Furtherly，the recovery rate of shale treated by the agent was satisfactory，being of 74.23%. In addition，the 3% plugging and inhibiting agent ensured the rheological property and filtration steady for drilling before and after aging and showed a slight increases in HTHP filtration as well as shale recovery rate. Based on results，the MOF-derived plugging and inhibiting agent has excellent sealing ability，inhibition and compatibility.