In the process of oilfield development，due to the influence of routine well workover，oil recovery and stratum structure，outputting oil and injecting water well tubers often have problems such as water channeling of outside tubes or drilling fluid loss，which seriously affects the oil production rate and the service life of oil or water wells. Therefore，in this paper，the epoxy resin was selected as the main agent for sealing channeling，and the effects of active diluent（glycidyl butyl ether）dosage， curing agent TEA dosage and silane coupling agent KH-560 dosage on curing time，curing strength and sealing channeling of epoxy resin adhesive plugging agent were studied. The research results showed that the optimal dilution ratio of epoxy resin plugging agent was 15%，accounting for epoxy resin dosage，and by adjusting the dosage of curing agent in range of 10%—20%，the curing time of epoxy resin plug sealing agent could be controlled within 2—5 h，and the compressive strength of colloid plug could reach above 20 MPa，and the sealing strength was 5.57 MPa. By adding 3%—4% silane coupling agent，the sealing strength could be increased two times. The plugging agent had good sealing and channeling performance，and could completely meet the requirements of casing sealing and channeling. According to the simplified chemical reaction kinetic model of epoxy resin curing，the relationship between gel time and temperature of the resin rubber plugging agent was simulated，which had guiding significance for field construction.