In order to meet the high temperature and high salinity environment of special reservoirs，such as Qinghai and Tarim， deep oil displacement profile control agent was prepared using temperature and salt resistant polymer SD6800，cross-linking agent， improver and stabilizer. The temperature resistance，injection property，liquidity，plugging property，scour resistance and oil displacement performance of the oil displacement profile control agent were studied. Finally，field tests were conducted in Tarim oil reservoir. The research results showed that the optimum formula of the oil displacement profile control agent was obtained as follows：0.5%—2.0% SD6800，50∶1 mass ratio of SD6800 and crosslinker，0.2% improver，0.1% stabilizer. As the concentration of SD6800，cross-linking agent or improver increased，the gelation speed and the apparent viscosity increased. But if the concentration of cross-linking agent or improver was too high，the gelation was prone to cross-linking excessive and caused dehydration. The stabilizer could remove free oxygen ions and improve the stability of gel system. As the temperature increased，the gelation speed and the strength increased，but at the same time the elasticity and stability of the oil displacement profile control agent became worse. The oil displacement profile control agent could be stable for more than 60 days under the condition of 150℃ and 25×104mg/L salinity. The oil displacement profile control agent had good temperature and salt resistance，liquidity，plugging performance，and scour resistance. The field application results showed that the oil displacement profile control agent system could effectively alleviate intra- and inter-layer contradictions in the reservoir，block high-permeability channels，improve the liquid absorption profile of the reservoir，increase wellhead pressure and reduce apparent water absorption index. The effect of increasing oil and reducing water content was obvious.