In order to improve formation heterogeneity of stratum，increase sweep volume of displacement agent，reduce water injection pressure and increase water injection capacity，a kind of particle plugging agent SDJ with good salt and acid resistancewas selected from the aspects of expansion ratio，acid resistance and plugging performance. The results showed that the swelling ratio of SDJ was 8.5 times in simulated brine with salinity of 50000 mg/L at the temperature of 60℃. The swelling retention rate was up to 20.83% after acidification treatment. The plugging rate in sand filling pipe with permeability of 997×10^-3 μm² was over 99.5%. The plugging rate in core with permeability of 1.824×10^-3 μm² was 94.7%. Field test results showed that the pressure was raised by 2.0 MPa after injection of the acid-resistant granules，and the water injection displacement was increased by 40.6% after acid injection，and the water injection pressure was reduced by 6.0 MPa. The effect of depressurization and injection-increasing of SDJ was excellent，and the injection profile was modified obviously