In order to treat waste polysulfonated drilling fluid efficiently，on the basis of polysulfonated drilling fluid，composed of 3% bentonite + 3% SMP-2（high temperature resistance filtrate loss reducer）+ 3% SMC（high temperature resistance filtrate loss reducer ）+3% SPNH（filtrate loss reducer）+0.3%FA-367（coating agent）+0.2%XY-27（viscosity reducer）+3% sulfonated asphalt （inhibitor），the dispersion stability of polysulfonated drilling fluid system was measured by near infrared scanning dispersive stability analyzer，and the colloid stability of drilling fluid was quantitatively characterized by the value of turbiscan stability index（TSI） to study the effect of various treatment agents on the colloid stability of poly sulfonated drilling fluid. In addition，through the determination of apparent viscosity and Zeta potential of drilling fluid system， the influence mechanism of various treatment agents on the colloid stability of poly sulfonated drilling fluid was analyzed. The results showed that，the various treatment agents affected the stability of polysulfonated drilling fluid system. Compared to that of the complete system，the TSI of the system without inhibitor increased by 88.5%，the viscosity decreased by 74% and the absolute value of Zeta potential decreased by 9.2%；the TSI of system without amphoteric ion class coating agent and viscosity reducer decreased by 46.2%，viscosity decreased by 51.9% and the absolute value of Zeta potential increased by 16.1%；the TSI of system without high temperature resistance filtrate loss reducer SMP-2 and SMC decreased by 42.3%，viscosity increased by 10.4% and the absolute value of Zeta potential decreased by 33.3%； the TSI of system without filtrate loss reducer SPNH decreased by 19.2%，the viscosity decreased by 23.4% and the absolute value of Zeta potential decreased by 8%. It could be concluded that the sulfonated asphalt inhibitor affected the colloid stability of drilling fluid system by mainly changing viscosity，while the coating agent，viscosity reducer and diluent had an effect on the colloid stability of drilling fluid system mainly by changing Zeta potential，while the filtrate loss reducer affected the colloid stability by changing both viscosity and Zeta potential.