The reservoir of MPE3 block in Venezuela had heavy oil with high viscosity and oil layer with widely thickness and heterogeneities. In order to decrease the cost of thermal recovery and carbon emission， a novel cold production technology for heavy oil was studied in lab with homemade viscosity reducers and artificial cores under the reservoir condition of MPE3 block. The effect of profile control with gel treatment and viscosity reducer on oil displacement efficiency in the core was investigated. The results showed that the heavy oil in porous media could be split and then coated with the viscosity reducer to produce a phenomenon of granulating and viscosity reducing， which led to a higher oil recovery increment. If the core was treated with profile control before the viscosity reducer displacement， synergetic effect would happen both to increase sweeping efficiency of viscosity reducer to contact some more heavy oil and to boost the result of granulating and viscosity reducing. The higher the permeability of porous media， the easier the water channel passages were formed in drainage formation. The method of profile control including polymer gel treatment or alternative injection of N2 which applied together with the viscosity reducer displacement could enhance heavy oil recovery greatly. On the other hand， in the cold huff and puff process with gas liquid alternating injection， either stratum energy increased or formation fluid was stirred with gas-liquid， which made the viscosity reducer and heavy oil blend and formed emulsion with low viscosity easily. The oil recovery increment in the cold huff and puff process with gas liquid alternating injection could reach 16.10%OOIP.