In order to improve the simulation of physical model for low permeability fractured reservoir， a physical model was designed， which could adjust the width of fracture and measure the flow rate of matrix and fracture. The plugging strength performance of weak gel， pre-gel particle and their composite profile control system was evaluated， respectively， by using the fracture physical model. What’ s more， low permeability fractured cores flooding experiment was developed by using composite profile control system. The results showed that the plugging strength performance of the three systems decreased with increasing fracture width. When the fracture width was greater than 0.69 mm， the weak gel and pre-gel particle could not effectively block.With decreasing concentration of pre-gel particle， the injection volume and injection time increased when the injection pressure increased significantly， and the optimum injection concentration of pre-gel particle was 1000 mg/L. However， the maximum sealing pressure of composite profile control system was higher than that of weak gel and pre-gel particle in the same fracture width， and the content of pre-gel particle was relatively small.When the composite profile control system completely blocked the fracture， the recovery rate of low permeability fractured core increased from 5.33% to 45.58%， showing significant effect for oil recovery.