Based on molecular structure design to strengthen the bonding strength between amine inhibitor molecules and clay particles， choosing silane coupling agent KH-570 as key monomer， DMAA and DMDAAC as functional monomers， organosilicon-amine inhibitor called PKDAS with high temperature was synthesized by radical copolymerization. The heat resistance，adsorption property on clays and inhibition property to bentonite and mud shale were studied. The results showed that PKDAS was resistant to high temperature of 220℃. The adsorption capacity of PKDAS was stronger than that of inhibitor NH-1 and FA-367，the adsorption of PKDAS，NH-1 and FA-367 before aging on clay particles was 27.3，10.2 and 12.6 mg/g， respectively，while the relative parameters after aging for 16 hours at the temperature of 220℃ ，was 6.8，1.9 and 2.0 mg/g， respectively. The inhibiting property of PKDAS to bentonite and mud shale was excellent，which was superior than that of NH-1 and FA-367 at the high temperature. The extreme anti-pollution of bentonite in the 1% PKDAS solution，was 40% and 30%， respectively，before and after aging for 16 hours at the temperature of 220℃.Expansion height of mud shale in 2.0% PKDAS solution for 16 h after aging at the temperature of 220℃ was 0.57 mm，which was ， lower than that in NH-1 or FA-367 solution， being of 1.07 and 1.05 mm，respectively. The rolling recovery of the mud shale in the PKDAS ，NH-1 and FA-367 solutions after aging for 16 h at the temperature of 220℃ was 86.67%， 38.29% and 38.07%.