In order to better understand the interaction between crude oil and foam，the influence factors of foam-oil interaction stability were researched，including oil type ，oil phase content，surfactant concentration ，surfactant type，salinity ，alkyl chain length and polymer content. Under different experiment conditions ，the half-time of foam drainage in the absence and presence of oil was measured. The result showed that different crude oil had different effect on foam stability and TK 729 oil exhibited the strongest stability to foam. Light oil and heavy oil both improved foam stability within a certain range of oil content. Different surfactant systems exhibited different degrees of sensitivity to oil ，and anionic surfactant AS showed the best foam stability to oil.After adding20% TK729 oil to amphoteric surfactants MZ and AS compounded system （mass ratio1∶2），oil destabilized foam with surfactant concentration less than 0.05% while stabilized foam with concentration more than0.075%. The increase of salinity had an inverse effect on foam stability to oil. Oil stabilized foam when the salinity was less than 5 × 10⁴mg/L while destabilized foam when the salinity was larger than10× 10⁴mg/L. Additionally，the shorter the alkane chain length ，the higher the tendency of alkane to destabilize foam was. Long-chain alkane with more than 16carbon number showed stability to foam. Adding polymer to the aqueous phase improved the foam performance in the presence of oil，and the more dosage of polymer the better foam stability to oil was.