Taking reservoir and fluid of SZ36-1 Oilfield in Bohai as research object, the property of the profile control agent, channel sealing agent and cold production agent was evaluated using the value of viscosity and oil recovery as indicators, as well as the flooding performance of the above system separately and jointly was carried out. Results showed that the channel sealing agent (modified starch, main agent concentration 80000 mg/L, auxiliaries concentration 2150 mg/L) possessed better anti-dilution and anti-shear than common profile control agent (Cr³⁺ polymer gel, polymer concentration 4000 mg/L, mass ratio of polymer and Cr³⁺ 180:1) did. When Mixed at oil-water volume ratio 1:5 with cold production agent water solution, the crude oil was turned to be an oil-in-water emulsion, as a result, the viscosity and seepage resistance decreased accordingly, the oil viscosity decreased from 540 mPa·s to 3.4 mPa·s. With the increase of core heterogeneity, the oil recovery of water flooding decreased, however, the increments of oil recovery of combined measures(“profile control + cold production” , “channel sealing + cold production” ) increased. The increase of difference between “profile control + cold production” and “channel sealing + cold production” suggested that the better ability to the control profile of channel sealing agent forced more cold production agent to lower permeability layers and then the oil viscosity reduction area could be extended, which prominently improved flooding effect. In heterogeneous core with layer permeabilities of 6000×10^-3μm2, 2000×10^-3μm2, 200×10^-3μm2, respectively, the increased recovery of profile control, channel sealing, cold production, and combined measures “profile control + cold production” and “channel sealing + cold production” was 25.5%, 33.9%, 6.1%, 30.4% and 39.9%, respectively, which suggested that the fluid profile control ability of “channel sealing + cold production” was better and had higher increased recovery.