The dynamic interfacial tension of oil-water and the displacement effect of anion Gemini surfactants GA12-4-12 and dodecyl sulfate sodium were contrasted,and the displacement effect of the compound of GA12-4-12 and non-ionic surfactant ANT1,ANT2 was investigated in different permeability and salinity condition.The results showed that GA12-4-12 possessed superior interfacial activity and ability to enhance the oil recovery,especially when the concentration of CA12-4-12 was 800 mg/L,the enhancement of oil recovery was 11.67% based on 63.38% of water flooding.GA12-4-12 was suitable for medium and low permeability reservoirs,however,the ability to enhance the oil recovery gradually declined with increasing salinity.Compound oil displacement experiments showed that in 2.5 ×105 mg/L salinity conditions,the oil recovery of low permeability cores of 48.3×10-3 μm2 was enhanced by the SP1 system(400 mg/L GA12-4-12+100 mg/L ANT1) for 10.67% based on 60% of water flooding;in 5×104 mg/L salinity conditions,the oil recovery of middle-low permeability cores of 417×10-3 μm2 was enhanced by the SP2 system(400 mg/L GA12-4-12+100 mg/L ANT2)for 8.42% based on 57.89% of water flooding.