In view of the problems of gas channeling and wellhead pressure caused by high pressure and fracturing in the development of oil and gas fields, water-soluble resin was used as the main cementitious materials and a resin-based cementing fluid system at low and medium temperature was prepared. The engineering performance, anti-channeling ability, mechanical property, temperature resistance and curing kinetics of the system were studied. The results show that the density of the resin system can be adjusted to 1.20~1.80g/cm³ through the combination of weighting agent and suspending agent, and it has good flowing ability. The thickening time can be adjusted from 60 to 410 min by changing the dosage of curing agent and accelerator between 60℃ and 90℃. When the displacement efficiency is 91.5%, the consolidation strength of cured resin is 3.01 MPa, the interface breakthrough pressure is more than 12 MPa, which is much higher than that of conventional cement stone under similar displacement efficiency. The compressive strength of cured resin is above 50MPa after curing at 90℃ for 24h, and the elastic recovery rate is more than 85% after six cycles of alternating stress loading, which is better than that of ordinary set cement. The TG analysis demonstrates that initial decomposition temperature of cured resin is 398℃, which indicates that the resin-based cementing fluid has good temperature resistance. The curing kinetics equations of S-HR/CA-1and S-HR/DCY systems, and the relationship between curing degree and curing time was determined. The resin cementing fluid has consolidation strength and strong deformation recovery ability at the cementing interface, which is conducive to ensuring the long-term integrity and sealing performance of cementing material, and preventing fluid channeling of oil and gas wells. The study of curing kinetics provides a theoretical reference for the research and application of this kind of resin working fluid system.