In this work, we successfully synthesized the hyperbranched polyetheramine agent (HBEA) with higher ratio of amine groups as a shale inhibitor by the reaction of prepared aziridine and TAEEA made?from triethanolamine (D230) and 2-chloroethylamine hydrochloride (CEAH)，in which the metal organic framework (MOF) was employed as catalyst for ring-open polycondensation (ROP). Attributing to?its?high?ratio of amine groups, the HBEA exhibits larger amine density than the straight chain polyetheramine D230 and D400. Molecular?simulation modeling?study?indicate that the adsorption models of HBEA on clay surfaces are consistent?with that of D230 and D400, ?but the density and adsorption?energie of??a single molecule are significantly higher than?the?latter?two, emplying the excellent adsorption capacity of HBEA. The YP of slurry system containing the agent (1 wt.%) is only 7.0Pa as additive content of bentonite reaches to 25 wt.%. The swelling heights of bentonite in a system involving 2% additives reduce about 60% compared with fresh water system and the shale recovery rate is satisfactory (74.23%). Compared with the original polyetheramine inhibitors，the HBEA agent at condition of same chemical dosage ensures the rheological property and filtration steady for drilling before and after aging, meanwhile , it shows a slight decreases in HTHP filtration and a modest growth in shale recovery rate. These results support our prediction that the HBEA agent has excellent inhibition and compatibility.