Aiming at the increasingly prominent scaling and plugging problems in oil and gas field development，non-acidic plugging removal agents with chelating agents as the core component present significant technical advantages in treating acid-insoluble scales such as barium sulfate and strontium sulfate scales，protecting wellbore equipment，and reducing corrosion risks. At present，conventional non-acidic plugging removal fluids used in oil and gas fields are mainly based on traditional chelating agents such as ethylenediaminetetraacetic acid （EDTA） and diethylenetriaminepentaacetic acid （DTPA） . However，large-scale popularization and application are significantly restricted by high cost and limited environmental adaptability. The introduction of quantum chemical methods such as density functional theory （DFT） provides an efficient and accurate technical approach for the molecular design and performance optimization of chelating agents，which can offer important theoretical and technical support for the development of high-efficiency green plugging removal technologies for oil and gas fields. This paper systematically reviews the current status of reservoir scaling and scaling prediction technologies，focuses on the research progress and field application effects of non-acidic plugging removal agents，and discusses the design ideas and application value of chelating agents based on molecular computing techniques.