To solve the problem of scaling in the produced water of Huang 3 Chang 6 area，which leads to pipelines and devices blockage and seriously affects the operation of the gathering and transmission stations，the scaling mechanisms in the Huang 3 Chang 6 area was clarified through the analysis of water and scale samples from the gathering station and single well，and targeted scale inhibitors was developed，in addition，the application of the scale inhibitor in the field was mentioned. it was determined that the main reason for severe scale blockage in the Huang 3 Chang 6 area gathering and transportation station was the incompatibility of single well produced water，which leaded to barium strontium sulfate scaling and blockage in gathering and transportation system. A highly efficient barium strontium scale inhibitor，mass ratio of HDTMPA to P-M-P（5000）being of 4∶1，was developed. The inhibition rate of barium sulfate scale was 90.9% when the concentration of the scale inhibitor was 60 mg/L. The indoor applicability evaluation test showed that the scale inhibition rates of the scale inhibitor on the simulated water of the A and B gathering station manifold was as high as 90% and 93%，respectively. the on-site application test of the scale inhibitor showed that the scale inhibitor significantly reduced the scaling degree in the gathering and transmission stations stations A and B，indicating that the application of the scale inhibitor could effectively solve the scaling problem and ensure the long-term stable operation of the Huang 3 Chang 6 area gathering and transmission stations.