In order to improve the high temperature resistance and low damage performance of fracturing fluid thickener，the fracturing fluid thickener （ADAN） was prepared by aqueous free radical polymerization using acrylamide （AM）， methylacryloxyethyl trimethylammonium chloride （ DMC ） ， 2-acrylamido-2-methylpropanesulfonic acid （ AMPS ） and N-vinylpyrrolidone（NVP）as monomers. The preparation conditions were optimized by single factor variable method，the structure and stability of ADAN were analyzed，and then the temperature and shear resistance，resistance reduction，static sand carrying and breaking properties of the fracturing fluid containing ADAN were evaluated. The results showed that the optimum copolymer ratio and reaction conditions were obtained as follows：20% monomer in total mass of reaction system，14∶2∶3∶1 the molar ratio of 4 monomers（AM，AMPS，DMC，NVP），0.4% initiator（K2SO3 and NaHSO3 with mass ratio of 1∶1）in total mass of reaction system，7 pH value，45 ℃ reaction temperature，8 h reaction time. ADAN prepared under these conditions had good thermal stability. The mass loss was about 10% at 40—260 ℃ . The fracturing fluid prepared with 0.8% ADAN，organozirconium crosslinking agent，high temperature stabilizer sodium sulfite and gel breaker ammonium persulfate had good temperature and shear resistance，resistance reduction，static sand carrying and breaking properties. The viscosity was still higher than 90 mPa·s after shearing for 140 min at 200 ℃ and 170 s^-1. In the flow range of 100—160 L/min，the resistance reduction rate increased from 48%to 63% . The settling distance and settling velocity of ceramic particles were 6.3 cm and 0.875 × 10^-2 cm/min after standing in fracturing fluid for 12 h. The residue content after gel breaking was 86 mg/L. ADAN fracturing fluid could withstand the high temperature of 200 ℃，meanwhile the damage to the reservoir was less，which met the needs of field construction and formation.