With the application of polymer flooding，partially hydrolyzed polyacrylamide（HPAM）has the problems of easy hydrolysis and low viscosity in high-temperature and high-salinity（HTHS）reservoir. To meet the requirement of harsh reservoir，a salt-resistant monomer 3-（N-allyl-N-methylamino）propane-1-sulfonate sodium（MAPS）was synthesized using allyl chloride and sodium N-methyl taurate as main materials，and MAPS and acrylamide（AM）were further copolymerized to form a novel salt-resistant polymer P（AM/MAPS）. The product was characterized by infrared spectroscopy and nuclear magnetic hydrogen spectroscopy. The effects of concentration，temperature，salinity and shear rate on the viscosity of P（AM/MAPS）were studied by rheometer. The results showed that the viscosity of P（AM/MAPS）solution with mass concentration of 2000 mg/L reached 14.20 mPa·s under the conditions of the temperature of 85 ℃ and salinity of 3×10⁴ mg/L. In one-dimensional displacement experiment with permeability of 527.73×10^-3 μm² sand pack tube，P（AM/MAPS）could enhanced oil recovery by 13.42% on the basis of water flooding，and the total recovery rate of the double-pipe parallel core with permeability of 882.79×10^-3 ，422.53×10^-3 μm² could enhanced by 9.27%. The salt-resistant polymer P（AM/MAPS）could be efficiently used in polymer flooding technology for HTHS reservoir to enhanced oil recovery.