Aiming at the issue of low water flooding efficiency in Bohai X oilfield due to the properties of high porosity，high permeability，strong heterogeneity，high water-oil mobility ratio in reservoir，an in-depth conformance control and flooding technique of controllable self-aggregation microspheres cooperating with emulsification dispersion agent，was proposed to enhance the oil recovery in the study. The self-aggregation property of the microspheres was studied by scanning electron microscope and particle size analysis，the emulsification property of the emulsion dispersion agent was evaluated by stirring emulsification method， and the performance of the two agents in reservoir was evaluated by sand pack experiment. The results showed that the microspheres could implement self-aggregation through the functionalized chains on the surface under reservoir conditions，and the particle size after aggregation was 3.1 times larger than that before aggregation. The injection pressure of the microspheres in sand packing model increased step by step， revealing the good injectivity and deep migration capability of the microspheres before self-aggregation，and the plugging rate after self-aggregation in the sand packing model with the permeability of 2000×10^-3—2600× 10^-3 μm² could be more than 50%. The selected emulsification dispersion agent could emulsify crude oil efficiently. The emulsification rate of crude oil could be 100% as the concentration of the agent was higher than 2000 mg/L，and the micro-homogeneity of the formation could be finely adjusted by emulsified crude oil. There was a good synergistic effect between the microspheres and emulsification dispersion agent. The oil recovery could be increased by 13.1%—18.4% compared with water flooding when the slug ratio of microspheres（6000 mg/L）and emulsification dispersion agent（4000 mg/L）was 1∶1—3∶1 with the total injection volume of 1 PV. The pilot tests showed that the technique proposed could obviously enhance oil recovery，the net oil recovery increased in three months was 3260.41 m³.