Rock wettability has an important effect on delaying the rise of water cone after the water cone is pressed in bottom water reservoir，but the degree of influence is not clear. Therefore，four kinds of wetting agents with different wetting abilities were preferred with the contact angle as an index. The wetting agents were dissolved in oil-soluble viscosity reducer，then the effects of the viscosity reducing system on viscosity reduction of heavy oil and inhibition of water cone rise again were evaluated. The internal relationship between wettability and production physical condition was quantitatively described. The action mechanism of the wetting agent was analyzed. The results showed that the four wetting agents had no effect on the viscosity reducing performance of viscosity reducer. The reservoir under the action of lipophilic wetting agent had the best effect of restraining the rise again of bottom water. The equilibrium pressure ratio reached 3.75，meanwhile the net recovery degree was increased by 15.17%. However，the equilibrium pressure ratio of the reservoir under the action of a strong hydrophilic wetting agent was only 0.54，meanwhile the net recovery degree was increased by 6.51% . There was obvious regularity between wettability and recovered physical property. Adjusting the wettability of reservoir could effectively restrain the rise again of water cone，and therefore improve the oil recovery.