Amphoteric gelling agent has the advantages of low price and convenient synthesis. It can improve the viscosity of acid based on the supramolecular effect of gelling agents. In order to construct the gelling acid system which can be applied in deep acidification fracturing well for a long time， two amphoteric gelling agents were synthesized from acrylamide （AM）， 2-acrylamide-2-methylpropanesulfonic acid（AMPS），dimethyl diallyl ammonium chloride（DMDAAC）or methacryloyloxyethyl trimethyl ammonium chloride（DMC）by free radical aqueous solution polymerization. The preparation conditions of gelling agents were optimized，and then the acid dissolving time，viscosity and temperature and shear resistance of gelling agents in acid solution were investigated. The results showed that the acid dissolving time of two amphoteric gelling agents were less than 40 min. Meanwhile，the viscosity increasing performance was good. The viscosity of acid containing the compound of two amphoteric gelling agents mixed in mass ratio 7∶3 was 39 mPa·s at 25 ℃ and 170 s^-1，while that was 15 mPa·s at 160 ℃ and 170 s^-1 after continuous shearing for 90 min. Compared with a single gelling agent，the compound gelling agent had better viscosity increasing property，temperature resistance and shear resistance performance.