In order to solve the problems faced by the current profile control and flooding combination technology in Bohai oilfield，and promote the oil increasing effect，BZ34-2/4 reservoir was taken as the simulation object，and the injection parameters and combination mode of profile control and flooding of phenolic gel/polymer microspheres were the optimized by the simulated experiments in heterogeneous cores. The results showed that phenolic gel，consisted of 3 g/L polymer，3 g/L phenolic resin crosslinking agent and 3 g/L resorcinol curing agent，had higher gelation strength and good plugging effect on high permeable layer. Supramolecular polymer microspheres with concentration of 3 g/L had good hydration swelling effect，which could achieve macro and micro fluid diversion effect. With the increase of core heterogeneity，water flooding recovery decreasesd，and the oil recovery of profile control and flooding presented a trend of "increase first and then decrease". From the technical and economic point of view，the reasonable injection timing of profile control and displacement control was 80%—90% of water cut，and the reasonable slug size of profile control agent was about 0.10—0.20 PV，and the reasonable slug size of flooding agent was about 0.20—0.30 PV. Compared with large slug and integral injection，small slug and multiple rounds of alternate injection could reduce the retention of microspheres at the injection end and slow down the inversion speed of profile，so as to improve the effect of fluid diversion.