Aiming at the characteristics of high-salt reservoirs in Yanmuxi oilfield and the technical requirements for enhanced oil recovery，the development of salt tolerant surfactant and reservoir adaptability was carried out. The results showed that the nonionic surfactant composite system DW-01 had the characteristics of low interfacial tension，strong anti-adsorption ability，excellent foaming effect and high oil displacement efficiency. When the concentration of DW-01 exceeded 0.05%，the oil-water interfacial tension could achieve ultra-low interfacial tension（10^-3 mN/m）and could still reach the order of 10^-2 mN/m after three times contact with oil sands. The injection of 0.4 PV DW-01 solution with the concentration of 0.3% could enhance oil recovery by more than 8% after water flooding，indicating that DW-01 had wonderful adaptability to the target reservoir. After water flooding，the surfactant mainly flowed along the dominant channel formed by water flooding，and unaffected area of water flooding was low. Hence，the surfactant must be used in combination with other flow diversion measures to achieve better increasing oil and decreasing water cut effect.