In order to clarify the feasibility of injection of profile control agent and profile control agent into target reservoir，the resistance coefficient，residual resistance coefficient and plugging rate of profile control agent and profile control agent in rock core was calculated through laboratory experiment，and the characteristics of pressure and diversion rate was analyzed，and the advantages and disadvantages of combination mode of profile control and displacement and target reservoir were determined. The results showed that at the temperature of 70 ℃ and at the injection rate of 0.9 mL/min，the adaptable permeability range of the initial low viscosity delayed crosslinking profile control agent should be between 1000 × 10^-3 μm² and 3000 × 10^-3 μm²，and the plugging rate was more than 95%，indicating that the plugging performance and fluid diversion effect was good. The adaptable permeability range of "Nano type" and "Supermolecule type A" polymer microsphere discontinuous profile control and flooding agent should be between 500×10^-3 μm² and 1000×10^-3μm² . In addition，compared to "Nano type" profile control and displacement agent，the "Supermolecule type A" profile control and displacement agent had better hydration expansion performance and deep profile control and displacement ability. With the increase of reservoir heterogeneity，the production degree of low-permeability reservoir decreased. When the permeability difference was greater than 8，the fluid diversion effect of profile control/profile control flooding combination mode was weakened.