In view of the problems of gas channeling and wellhead pressure caused by high pressure and fracturing in the development of oil and gas fields and periodicity pressure changing in gas storage，water-soluble resin（S-HR）and amines curing agent for medium temperature（CA-1）were used as the main cementitious materials and a resin-based well cementing fluid system applying to low and medium temperature was prepared. The engineering performance，anti-channeling performance，mechanical property，temperature resistance and curing kinetics of the system were studied. The results showed that the density of the resin system could be adjusted to 1.20—1.90 g/cm³ by changing the dosages of weighting agent barite and suspending agent micro-silica， and it had good flowing ability. The thickening time could be adjusted from 60 to 410 min between 60 ℃ and 90 ℃. When the displacement efficiency was 91.5%，the consolidation strength of cured resin was 3.01 MPa，the interface breakthrough pressure was more than 12 MPa，which was much higher than that of conventional cement stone under similar displacement efficiency. The compressive strength of cured resin was 53.2 MPa after curing at 90 ℃ for 24 h，and the elastic recovery rate was more than 85% after six cycles of alternating stress loading，which was better than that of conventional cement stone. The cured resin body had good temperature resistance and the initial decomposition temperature was 398 ℃. The curing kinetics equations of S-HR/CA-1 and S-HR/amines curing agent for high temperature（DCY）systems were determined by differential scanning calorimetry. The resin cementing fluid had high consolidation strength and strong deformation recovery ability at the cementing interface，which was conducive to ensuring the long-term integrity and sealing performance of cementing material，and preventing fluid channeling of oil and gas wells. The study of curing kinetics provided a theoretical reference for the research and application of this kind of resin working fluid system.