In view of the problems of poor water washing resistance of inorganic salt clay stabilizer，easy adsorption and blocking of pores and poor temperature resistance of polymer clay stabilizer，a small molecular clay stabilizer （ZWS-1） with high temperature resistance was synthesized by using trimethylamine and γ-chloropropyl triethoxysilane. The anti-swelling performance and temperature resistance of ZWS-1 were evaluated. The synergistic effect of ZWS-1 and KCl was investigated. And the anti-swelling mechanism of ZWS-1 was analyzed. The results showed that the optimum preparation condition of ZWS-1 was obtained as follows：1∶1.1 the molar ratio of silane to trimethylamine，90 ℃ synthesis temperature，40 h reaction time，and 5% potassium iodide. The temperature resistance of ZWS-1 was good and the optimum dosage of ZWS-1 was 1.5%. A synergistic effect was observed between 1.5% ZWS-1 and 4% KCl，whose anti-swelling rate was 98.3%，and the water washing resistance was 91.4% at 150 ℃. ZWS-1 leaded to the agglomeration of clay particles and increased the stability of clay. The chemical bonds were formed through the dehydration condensation reaction between ZWS-1 and hydroxyl groups on the surface of clay，which played a role in stabilizing clay.