In order to research the adsorption and retention law of chemicals agent in process of compound flooding in conglomerate reservoir，the interfacial property and the adsorption retention of chemical agents of the SP system/ASP system after conglomerate core sand adsorption at different liquid-solid ratios was investigated. The results showed that at different liquid-solid ratios，the interfacial tension between SP system/ASP system and the crude oil changed a little after four times of the conglomerate core sand adsorption，and the equilibrium interfacial tension（IFT_120min）could reach the requirement of ultra-low interfacial tension， being of 10^-3 mN/m. After four times of conglomerate core sand adsorption，the concentration of the chemical agents in SP system/ ASP system decreased with the increase of adsorption times. The reduction degree of the concentration of the chemical agents was arraged as follows，alkali concentration of ASP system＞surfactant concentration of ASP system＞surfactant concentraion of SP system＞polymer concentration of ASP system≈polymer concentration of SP system.