In order to meet the requirement of tertiary oil recovery technology under the condition of high temperature and high salt reservoir in Hade oilfield，Pickering emulsion template method was used to modify SiO2 nanoparticle with aminopropyl triethoxysilane and perfluorooctanoic acid，and amphiphilic nanoparticle with hydrophilic amino group and hydrophobic fluorocarbon chain was prepared. The effects of temperature and the concentration of Na+ and Ca2+ on the interfacial tension between amphiphilic nanoparticle dispersion fluid and simulated oil were studied. The migration law of nanoparticle in porous media and the performance of oil recovery were investigated. The results showed that the amphiphilic nanoparticle had good salt tolerance and temperature resistance. The dosage of Na + and Ca2 + and temperature had no significant effect on the interfacial activity of amphiphilic particle，and the interfacial tension between amphiphilic nanoparticle dispersion fluid and simulated oil maintained at the order of 10- 2 mN/m. Although the amphiphilic nanoparticles adsorbed on the pore surface of core，which slowed down the migration rate of some particles in amphiphilic nanoparticle dispersion fluid，desorption and migration of the core could be realized through Brownian motion. The final adsorption capacity of amphiphilic nanoparticle in porous media was less than 10%，showing excellent adsorption resistance. Amphiphilic nanoparticle could improve oil recovery under the condition of high temperature and high salt. Under the condition of 120 ℃ and salinity of 215 g/L，the recovery factor increased by 10.1 percentage points over water injection after 0.5 PV 0.6% amphiphilic nanoparticle dispersion solution was injected. Amphiphilic nanoparticle combined the advantage of molecular surfactant and homogeneous particle，and had good interfacial activity and stability.